Mstn^em#Gpli
Endonuclease-mediated Allele Detail

Summary

• Symbol: Mstn^em#Gpli
• Name: myostatin; endonuclease-mediated mutation, Guangpeng Li
• MGI ID: MGI:7518757
• Gene: Mstn Location: Chr1:53100799-53107238 bp, + strand Genetic Position: Chr1, 26.99 cM
• Alliance: Mstn^em#Gpli page

Mutation origin

• Strain of Origin: Not Specified

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: CRISPR/Cas9 technology targeting exon 3 generated deletions ranging from 5 to 8 nucleotides. The pound symbol (#) is used when line is not specified and/or lines are pooled. (J:338940)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mstn Mutation: 38 strains or lines available

References

• Original: J:338940 Gu M, et al., Myostatin Knockout Affects Mitochondrial Function by Inhibiting the AMPK/SIRT1/PGC1alpha Pathway in Skeletal Muscle. Int J Mol Sci. 2022 Nov 8;23(22)
• All: 1 reference(s)