Del(12Ighg3-Ighg2b)1Mzeng
Endonuclease-mediated Allele Detail

Summary

• Symbol: Del(12Ighg3-Ighg2b)1Mzeng
• Name: deletion, Chr 12, Melody Zeng 1
• MGI ID: MGI:7518234
• Synonyms: IgG KO
• Gene: Del(12Ighg3-Ighg2b)1Mzeng Location: unknown Genetic Position: Chr12, Syntenic

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intergenic deletion
• Del(12Ighg3-Ighg2b)1Mzeng involves 4 genes/genome features (Ighg2a, Ighg2b, Ighg1 ...) View all
• Mutation details: CRISPR/cas9 genome editing is used to delete the IgG region (approx. 80kbp) encompassing 1 kb upstream of Ighg3 and 1 kb downstream of Ighg2b. The deletion removed Ighg1, Ighg2a, Ighg2b, and Ighg3. (J:338906)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Del(12Ighg3-Ighg2b)1Mzeng Mutation: 1 strain or line available

References

• Original: J:338906 Sanidad KZ, et al., Maternal gut microbiome-induced IgG regulates neonatal gut microbiome and immunity. Sci Immunol. 2022 Jun 10;7(72):eabh3816
• All: 1 reference(s)