Nr1d1^em1Laz
Endonuclease-mediated Allele Detail

Summary

• Symbol: Nr1d1^em1Laz
• Name: nuclear receptor subfamily 1, group D, member 1; endonuclease-mediated mutation 1, Mitchell A Lazar
• MGI ID: MGI:7517201
• Synonyms: HA-REV-ERBalpha
• Gene: Nr1d1 Location: Chr11:98658758-98666159 bp, - strand Genetic Position: Chr11, 62.66 cM
• Alliance: Nr1d1^em1Laz page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Epitope tag, No functional change)
• Mutation: Insertion
• CRISPR/Cas9 technology inserted a 3xHA epitope tag in frame with the N terminus. (J:279346)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Nr1d1 Mutation: 44 strains or lines available

References

• Original: J:279346 Adlanmerini M, et al., Circadian lipid synthesis in brown fat maintains murine body temperature during chronic cold. Proc Natl Acad Sci U S A. 2019 Sep 10;116(37):18691-18699
• All: 3 reference(s)