Gt(ROSA)26Sor^{tm1(CAG-CD63/copGFP)Yoy}
Targeted Allele Detail

Summary

• Symbol: Gt(ROSA)26Sor^{tm1(CAG-CD63/copGFP)Yoy}
• Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 1, Yongjie Yang
• MGI ID: MGI:7517186
• Synonyms: CD63-GFP^f
• Gene: Gt(ROSA)26Sor Location: Chr6:113044389-113054205 bp, - strand Genetic Position: Chr6, 52.73 cM
• Alliance: Gt(ROSA)26Sor^{tm1(CAG-CD63/copGFP)Yoy} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:279328
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Targeted (Conditional ready, Epitope tag, Humanized sequence, Inserted expressed sequence, Reporter)
• Mutation: Insertion
• Gt(ROSA)26Sor^{tm1(CAG-CD63/copGFP)Yoy} expresses 1 gene
  Knock-in expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  CD63 (967)

  Cd63	(MGI:99529)

• Mutation details: A CAG promoter, FRT site, loxP-flanked STOP cassette, human CD63-copGFP-6X His, WPRE, polyA signal, AttB site, Pr, second FRT site, neomycin resistance gene, poly A signal, and AttP site were inserted in the intron between exons 1 and 2. The copGFP is a variant of GFP, cloned from copepod Pontellina plumata. (J:279328)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Gt(ROSA)26Sor Mutation: 1062 strains or lines available

References

• Original: J:279328 Men Y, et al., Exosome reporter mice reveal the involvement of exosomes in mediating neuron to astroglia communication in the CNS. Nat Commun. 2019 Sep 12;10(1):4136
• All: 5 reference(s)