Tg(TH-ALK*F1174L)5Homy
Transgene Detail

Summary

• Symbol: Tg(TH-ALK*F1174L)5Homy
• Name: transgene insertion 5, Hiroaki Honda
• MGI ID: MGI:7517126
• Transgene: Tg(TH-ALK*F1174L)5Homy Location: unknown
• Alliance: Tg(TH-ALK*F1174L)5Homy page

Transgene origin

• Strain of Origin: C57BL/6N

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(TH-ALK*F1174L)5Homy expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  ALK (238)

  Alk	(MGI:103305)

• Tg(TH-ALK*F1174L)5Homy expression driven by 1 gene
  Transgene expression driven by:
  

  Organism

  Driver Gene

  Homolog in Mouse

  Note

  human

  TH (7054)

  Th	(MGI:98735)

• Mutation details: The transgene contains the human tyrosine hydroxylase promoter, human ALK cDNA (F1174L mutant), rabbit beta globin intron, and Herpes simplex virus HSV terminator. (J:338891)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:338891 Chen Y, et al., Oncogenic mutations of ALK kinase in neuroblastoma. Nature. 2008;455(7215):971-4
• All: 1 reference(s)