Usp20^em1Shes
Endonuclease-mediated Allele Detail

Summary

• Symbol: Usp20^em1Shes
• Name: ubiquitin specific peptidase 20; endonuclease-mediated mutation 1, Sudha K Shenoy
• MGI ID: MGI:7517045
• Synonyms: USP20-S334A
• Gene: Usp20 Location: Chr2:30872291-30912667 bp, + strand Genetic Position: Chr2, 21.77 cM, cytoband B
• Alliance: Usp20^em1Shes page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Not Applicable)
• Mutation: Single point mutation
• Mutation details: CRISPR/Cas9 technology generated a serine to alanine substitution at residue 334 (p.S334A). This mutation mimics unphosphorylated USP20. (J:338880)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Usp20 Mutation: 53 strains or lines available

References

• Original: J:338880 Zhang L, et al., Phosphorylation of USP20 on Ser334 by IRAK1 promotes IL-1beta-evoked signaling in vascular smooth muscle cells and vascular inflammation. J Biol Chem. 2023 Jul;299(7):104911
• All: 1 reference(s)