Pla2g4a^tm1Cect
Targeted Allele Detail

Summary

• Symbol: Pla2g4a^tm1Cect
• Name: phospholipase A2, group IVA (cytosolic, calcium-dependent); targeted mutation 1, Charles E Chalfant
• MGI ID: MGI:7516728
• Gene: Pla2g4a Location: Chr1:149705369-149837041 bp, - strand Genetic Position: Chr1, 63.51 cM
• Alliance: Pla2g4a^tm1Cect page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:295310
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: The targeting construct inserted into intron three a loxP site-flanked puromycin resistance gene followed by a premature stop codon and a modified exon 4 with the mutation responsible for the amino acid substitution of arginine, lysine, and arginine to alanine at positions 57, 58, and 59 (R57A, K58A, and R59A) in the C1P binding site. (J:295310)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pla2g4a Mutation: 64 strains or lines available

References

• Original: J:295310 MacKnight HP, et al., The interaction of ceramide 1-phosphate with group IVA cytosolic phospholipase A2 coordinates acute wound healing and repair. Sci Signal. 2019 Dec 3;12(610)
• All: 1 reference(s)