Tent5a^em3Adki
Endonuclease-mediated Allele Detail

Summary

• Symbol: Tent5a^em3Adki
• Name: terminal nucleotidyltransferase 5A; endonuclease-mediated mutation 3, Andrzej Dziembowski
• MGI ID: MGI:7515010
• Synonyms: Tent5a^flox
• Gene: Tent5a Location: Chr9:85202492-85209203 bp, - strand Genetic Position: Chr9, 46.04 cM
• Alliance: Tent5a^em3Adki page

Mutation origin

• Strain of Origin: (C57BL/6JTar x CBA/WTar)F1

Mutation description

• Allele Type: Endonuclease-mediated (Conditional ready)
• Mutation: Insertion
• Mutation details: CRISPR/Cas9 technology inserted loxP sites in introns flanking exon 2, which contains triplets encoding the catalytic center of the protein (D144N and D146N). (J:337629)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tent5a Mutation: 21 strains or lines available

References

• Original: J:337629 Liudkovska V, et al., TENT5 cytoplasmic noncanonical poly(A) polymerases regulate the innate immune response in animals. Sci Adv. 2022 Nov 18;8(46):eadd9468
• All: 2 reference(s)