Trpa1^{tm1.1(cre)Kzim}
Targeted Allele Detail

Summary

• Symbol: Trpa1^{tm1.1(cre)Kzim}
• Name: transient receptor potential cation channel, subfamily A, member 1; targeted mutation 1.1, Katharina Zimmermann
• MGI ID: MGI:7514628
• Synonyms: TRPA1-IC
• Gene: Trpa1 Location: Chr1:14942872-14989086 bp, - strand Genetic Position: Chr1, 4.5 cM
• Alliance: Trpa1^{tm1.1(cre)Kzim} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:338729
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Recombinase)
• Mutation: Insertion
• Trpa1^{tm1.1(cre)Kzim} expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Trpa1 (MGI:3522699)

• Mutation details: The targeting construct inserted an IRES-Cre-pgk promoterdriven Flp recombination target (FRT)neomycin (neo)FRT cassette downstream of the stop codon in the exon 27of the Trpa1 gene by homologous recombination in ES cells. The FRT flanked neo selection cassette was removed by FLP-deleter mice. (J:338729)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Trpa1 (mouse) Summary of all recombinase alleles driven by Trpa1. Comparative matrix view of recombinase activities Alliance mouse Trpa1 gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Trpa1 Mutation: 92 strains or lines available

References

• Original: J:338729 Bernal L, et al., Odontoblast TRPC5 channels signal cold pain in teeth. Sci Adv. 2021 Mar;7(13)
• All: 1 reference(s)