Ets1^em1Shyi
Endonuclease-mediated Allele Detail

Summary

• Symbol: Ets1^em1Shyi
• Name: Ets proto-oncogene 1, transcription factor; endonuclease-mediated mutation 1, Sin-Hyeog Im
• MGI ID: MGI:7514383
• Synonyms: Ets1^flox
• Gene: Ets1 Location: Chr9:32547517-32669116 bp, + strand Genetic Position: Chr9, 17.97 cM
• Alliance: Ets1^em1Shyi page

Mutation origin

• Strain of Origin: Not Applicable

Mutation description

• Allele Type: Endonuclease-mediated (Conditional ready, No functional change)
• Mutation: Insertion
• Exon 7, encoding a DNA binding domain, was flanked by loxP sites via CRISPR/Cas9 technology. (J:285365)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ets1 Mutation: 27 strains or lines available

References

• Original: J:285365 Kim CJ, et al., The Transcription Factor Ets1 Suppresses T Follicular Helper Type 2 Cell Differentiation to Halt the Onset of Systemic Lupus Erythematosus. Immunity. 2018 Dec 18;49(6):1034-1048.e8
• All: 2 reference(s)