Syngap1^em1Rumb
Endonuclease-mediated Allele Detail

Summary

• Symbol: Syngap1^em1Rumb
• Name: synaptic Ras GTPase activating protein 1 homolog (rat); endonuclease-mediated mutation 1, Gavin Rumbaugh
• MGI ID: MGI:7514375
• Synonyms: Syngap1^B*
• Gene: Syngap1 Location: Chr17:27160227-27191408 bp, + strand Genetic Position: Chr17, 13.6 cM
• Alliance: Syngap1^em1Rumb page

Mutation origin

• Strain of Origin: Not Specified

Mutation description

• Allele Type: Endonuclease-mediated (Modified isoform(s))
• Mutation: Single point mutation
• Mutation details: CRISPR/cas9-mediated recombination converted the exon 19a splice acceptor site from 'AAG' to 'ACG'. Expression of the beta isoform is essentially absent while expression of the alpha 1 and 2 isoforms is increased. (J:338643)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Syngap1 Mutation: 50 strains or lines available

References

• Original: J:338643 Kilinc M, et al., Endogenous Syngap1 alpha splice forms promote cognitive function and seizure protection. Elife. 2022 Apr 8;11:e75707
• All: 1 reference(s)