C9orf72^em2Fehu
Endonuclease-mediated Allele Detail

Summary

• Symbol: C9orf72^em2Fehu
• Name: C9orf72, member of C9orf72-SMCR8 complex; endonuclease-mediated mutation 2, Fenghua Hu
• MGI ID: MGI:7514281
• Synonyms: C9orf72^-
• Gene: C9orf72 Location: Chr4:35191285-35226153 bp, - strand Genetic Position: Chr4, 17.13 cM
• Alliance: C9orf72^em2Fehu page

Mutation origin

• Strain of Origin: (C57BL/6J x FVB/N)F1

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: CRISPR/cas9 endonuclease-mediated genome editing is used to target exon 2. The founder contains a 108 nucleotide deletion (including the start codon. Western blot confirms the loss of isoform I. (J:338627)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any C9orf72 Mutation: 43 strains or lines available

References

• Original: J:338627 Pang W, et al., C9ORF72 suppresses JAK-STAT mediated inflammation. iScience. 2023 May 19;26(5):106579
• All: 1 reference(s)