Rbm20^em1Wguo
Endonuclease-mediated Allele Detail

Summary

• Symbol: Rbm20^em1Wguo
• Name: RNA binding motif protein 20; endonuclease-mediated mutation 1, Wei Guo
• MGI ID: MGI:7514177
• Synonyms: Rbm20^deltaRS
• Gene: Rbm20 Location: Chr19:53665737-53855511 bp, + strand Genetic Position: Chr19, 48.28 cM
• Alliance: Rbm20^em1Wguo page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Not Applicable)
• Mutation: Intragenic deletion
• Mutation details: CRISPR/Cas9 technology generated a 102 bp deletion from E633 to S666 of the arginine-rich (RS) domain. (J:338607)

Expression

In Mice Carrying this Mutation:

1 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rbm20 Mutation: 57 strains or lines available

References

• Original: J:338607 Zhang Y, et al., Disruption of the nuclear localization signal in RBM20 is causative in dilated cardiomyopathy. JCI Insight. 2023 Jul 10;8(13)
• All: 1 reference(s)