Nsun5^em1Mscho
Endonuclease-mediated Allele Detail

Summary

• Symbol: Nsun5^em1Mscho
• Name: NOL1/NOP2/Sun domain family, member 5; endonuclease-mediated mutation 1, Markus Schosserer
• MGI ID: MGI:7514105
• Gene: Nsun5 Location: Chr5:135398807-135405659 bp, + strand Genetic Position: Chr5, 75.16 cM
• Alliance: Nsun5^em1Mscho page

Mutation origin

• Strain of Origin: Not Specified

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Insertion
• Mutation details: CRISPR/Cas9 genome editing technology was used to generate a disruption of exon 1, intron 1 and parts of exon 2 with two loxP-sites. (J:287064)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Nsun5 Mutation: 27 strains or lines available

References

• Original: J:287064 Heissenberger C, et al., Loss of the ribosomal RNA methyltransferase NSUN5 impairs global protein synthesis and normal growth. Nucleic Acids Res. 2019 Dec 16;47(22):11807-11825
• All: 1 reference(s)