Amhr2^em1(icre)Fjd
Endonuclease-mediated Allele Detail

Summary

• Symbol: Amhr2^em1(icre)Fjd
• Name: anti-Mullerian hormone type 2 receptor; endonuclease-mediated mutation 1, Franco J DeMayo
• MGI ID: MGI:7513976
• Synonyms: Amhr2-iCre(Fjd)
• Gene: Amhr2 Location: Chr15:102353802-102363068 bp, + strand Genetic Position: Chr15, 57.58 cM
• Alliance: Amhr2^em1(icre)Fjd page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:335505
• Parent Cell Line: G4 (ES Cell)
• Strain of Origin: (129S6/SvEvTac x C57BL/6NCrl)F1

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout, Recombinase)
• Mutations: Insertion, Intragenic deletion
• Amhr2^em1(icre)Fjd expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Amhr2 (MGI:105062)

• Mutation details: Using CRISPR/Cas9 technology, the codon improved iCre recombinase open reading frame (ORF) and Sv40 polyadenylation sequence replaced the genomic sequence immediately downstream of the start codon in exon 1 of the Amhr2. (J:335505)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Amhr2 (mouse) Summary of all recombinase alleles driven by Amhr2. Comparative matrix view of recombinase activities Alliance mouse Amhr2 gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Amhr2 Mutation: 27 strains or lines available

References

• Original: J:335505 Dickson MJ, et al., iCre recombinase expressed in the anti-Mullerian hormone receptor 2 gene causes global genetic modification in the mouse. Biol Reprod. 2023 Apr 11;108(4):575-583
• All: 1 reference(s)