Tg(Pcp2-ATXN3*69Q)1Hirai
Transgene Detail

Summary

• Symbol: Tg(Pcp2-ATXN3*69Q)1Hirai
• Name: transgene insertion 1, Hirokazu Hirai
• MGI ID: MGI:7513806
• Synonyms: Tg(Pcp2-HA/ATXN3*69Q)1Hirai
• Transgene: Tg(Pcp2-ATXN3*69Q)1Hirai Location: unknown
• Alliance: Tg(Pcp2-ATXN3*69Q)1Hirai page

Transgene origin

• Strain of Origin: C57BL/6NCrSlc

Transgene description

• Transgene Type: Transgenic (Epitope tag, Inserted expressed sequence)
• Mutation: Insertion
• Tg(Pcp2-ATXN3*69Q)1Hirai expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Pcp2 (MGI:97508)

• Tg(Pcp2-ATXN3*69Q)1Hirai expression driven by 1 gene
  Transgene expression driven by:
  

  Organism

  Driver Gene

  Homolog in Mouse

  Note

  human

  ATXN3 (4287)

  Atxn3

  (MGI:1099442)

  human sequence has a 69 Q repeat

• Mutation details: The cDNA encoding a N-terminal-truncated form (lacking 286 amino-acid residues) of human ATAXIN-3 with 69 glutamine repeats is driven by a Purkinje-cell specific L7 promoter (Pcp2). The ATG start codon in exon 2 of Pcp2 was mutated to inhibit the expression of exons 1-3. In addition an N-terminal hemagglutinin epitope was added. (J:136101)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:104881 The RIKEN BioResource Center, Information obtained from The RIKEN BioResource Center. Unpublished. 2006-2013
• All: 2 reference(s)