Prcp^em1Xwg
Endonuclease-mediated Allele Detail

Summary

• Symbol: Prcp^em1Xwg
• Name: prolylcarboxypeptidase (angiotensinase C); endonuclease-mediated mutation 1, Xin Wang
• MGI ID: MGI:7512784
• Gene: Prcp Location: Chr7:92524461-92583789 bp, + strand Genetic Position: Chr7, 51.64 cM, cytoband E2
• Alliance: Prcp^em1Xwg page

Mutation origin

• Strain of Origin: Not Specified

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• CRISPR/Cas9 genome editing technology was used to generate a deletion of the entire 162bp exon 1. (J:338426)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Prcp Mutation: 28 strains or lines available

References

• Original: J:338426 Nguyen BY, et al., Prolylcarboxypeptidase Alleviates Hypertensive Cardiac Remodeling by Regulating Myocardial Tissue Angiotensin II. J Am Heart Assoc. 2023 Jun 20;12(12):e028298
• All: 1 reference(s)