Taf8^tm1.1Avo
Targeted Allele Detail

Summary

• Symbol: Taf8^tm1.1Avo
• Name: TATA-box binding protein associated factor 8; targeted mutation 1, Anne K Voss
• MGI ID: MGI:7511859
• Synonyms: Taf8^lox
• Gene: Taf8 Location: Chr17:47794289-47813216 bp, - strand Genetic Position: Chr17, 23.33 cM, cytoband C
• Alliance: Taf8^tm1.1Avo page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:262962
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 1 and an FRT-flanked neomycin resistance cassette and second loxP site were inserted downstream of exon 7. The neomycin resistance cassette was removed via flp-mediated recombination. (J:262962)

Expression

In Mice Carrying this Mutation:

3 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Taf8 Mutation: 26 strains or lines available

References

• Original: J:262962 El-Saafin F, et al., Homozygous TAF8 mutation in a patient with intellectual disability results in undetectable TAF8 protein, but preserved RNA polymerase II transcription. Hum Mol Genet. 2018 Jun 15;27(12):2171-2186
• All: 3 reference(s)