Ptk2b^em1Yank
Endonuclease-mediated Allele Detail

Summary

• Symbol: Ptk2b^em1Yank
• Name: PTK2 protein tyrosine kinase 2 beta; endonuclease-mediated mutation 1, Yanping Kuang
• MGI ID: MGI:7511566
• Synonyms: Ptk2b^-
• Gene: Ptk2b Location: Chr14:66390706-66518501 bp, - strand Genetic Position: Chr14, 34.36 cM
• Alliance: Ptk2b^em1Yank page

Mutation origin

• Strain of Origin: Not Applicable

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: An 8 bp deletion (CCTGAGGG) was created in exon 1 using an sgRNA (targeting GGCACTTTACGCCGGCCTGA) with CRISPR/Cas9 technology. (J:307509)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ptk2b Mutation: 55 strains or lines available

References

• Original: J:307509 Cong Y, et al., Ptk2b deletion improves mice folliculogenesis and fecundity via inhibiting follicle loss mediated by Erk pathway. J Cell Physiol. 2021 Feb;236(2):1043-1053
• All: 1 reference(s)