Caln1^em1Mrkr
Endonuclease-mediated Allele Detail

Summary

• Symbol: Caln1^em1Mrkr
• Name: calneuron 1; endonuclease-mediated mutation 1, Michael Kreutz
• MGI ID: MGI:7510163
• Synonyms: Caln-1^-
• Gene: Caln1 Location: Chr5:130398296-130876253 bp, + strand Genetic Position: Chr5, 69.29 cM, cytoband F
• Alliance: Caln1^em1Mrkr page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: CRISPR/Cas9 genome editing technology was used to generate a deletion of exon 2. Western blot analysis of hippocampal and cerebellar lysates confirmed the absence of protein expression in homozygous mutant mice. (J:338143)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Caln1 Mutation: 14 strains or lines available

References

• Original: J:338143 Andres-Alonso M, et al., Golgi satellites are essential for polysialylation of NCAM and expression of LTP at distal synapses. Cell Rep. 2023 Jun 23;42(7):112692
• All: 1 reference(s)