Tafazzin^tm2.1Dost
Targeted Allele Detail

Summary

• Symbol: Tafazzin^tm2.1Dost
• Name: tafazzin, phospholipid-lysophospholipid transacylase; targeted mutation 2.1, Douglas Strathdee
• MGI ID: MGI:7509861
• Synonyms: Taz KO
• Gene: Tafazzin Location: ChrX:73325518-73333757 bp, + strand Genetic Position: ChrX, 37.95 cM, cytoband C1-C3
• Alliance: Tafazzin^tm2.1Dost page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:274911
• Parent Cell Line: HM-1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd-Hprt1^b-m3

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Two loxP sites flank exons 510 of the gene. Cre-mediated recombination in the germline resulted in the deletion of the flanked exons. (J:274911)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tafazzin Mutation: 2 strains or lines available

References

• Original: J:274911 Ren M, et al., Extramitochondrial cardiolipin suggests a novel function of mitochondria in spermatogenesis. J Cell Biol. 2019 May 6;218(5):1491-1502
• All: 1 reference(s)