Sall1^em1Glass
Endonuclease-mediated Allele Detail

Summary

• Symbol: Sall1^em1Glass
• Name: spalt like transcription factor 1; endonuclease-mediated mutation 1, Christopher K Glass
• MGI ID: MGI:7509096
• Synonyms: EKO
• Gene: Sall1 Location: Chr8:89753867-89770790 bp, - strand Genetic Position: Chr8, 43.51 cM, cytoband D
• Alliance: Sall1^em1Glass page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: CRISPR/cas9 endonuclease-mediated genome editing used sgRNA (protospacers: GAATGACCCTGGCAATCATG, TCCATAAG ATAGCTTAGGGA, CTTGACAG ACATTACACAGG, CTAGAATCGGCTTTGGTGCT) to delete a region spanning 13 kb. (J:337600)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Sall1 Mutation: 77 strains or lines available

References

• Original: J:337600 Fixsen BR, et al., SALL1 enforces microglia-specific DNA binding and function of SMADs to establish microglia identity. Nat Immunol. 2023 Jul;24(7):1188-1199
• All: 1 reference(s)