Tg(ACTA1-Lrp4*)#Bali
Transgene Detail

Summary

• Symbol: Tg(ACTA1-Lrp4*)#Bali
• Name: transgene insertion, Baoming Li
• MGI ID: MGI:7507173
• Synonyms: HSA::LRP4-deltaICD^Tg, LRP4-deltaICDtg
• Transgene: Tg(ACTA1-Lrp4*)#Bali Location: unknown
• Alliance: Tg(ACTA1-Lrp4*)#Bali page

Transgene origin

• Strain of Origin: Not Applicable

Transgene description

• Transgene Type: Transgenic (Epitope tag, Inserted expressed sequence)
• Mutation: Insertion
• Tg(ACTA1-Lrp4*)#Bali expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Lrp4 (MGI:2442252)	human promoter, N-terminal FLAG tag, mouse cDNA missing C-terminal intra-cellular domain sequence

• Tg(ACTA1-Lrp4*)#Bali expression driven by 1 gene
  Transgene expression driven by:
  

  Organism

  Driver Gene

  Homolog in Mouse

  Note

  human

  ACTA1 (58)

  Acta1

  (MGI:87902)

• Mutation details: The transgene contains the following elements: human skeletal muscle actin alpha 1 promoter, polyomavirus capsid protein gene VP1, signal peptide sequence, FLAG tag sequence in-frame with mouse low density lipoprotein receptor-related protein 4 cDNA sequence with the intracellular domain removed, IRES sequence, GFP reporter gene, and SV40 poly(A) signal sequences. (J:307970)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:307970 Jing H, et al., Synapse-specific Lrp4 mRNA enrichment requires Lrp4/MuSK signaling, muscle activity and Wnt non-canonical pathway. Cell Biosci. 2021 Jun 5;11(1):105
• All: 1 reference(s)