Mpeg1^em1Kozi
Endonuclease-mediated Allele Detail

Summary

• Symbol: Mpeg1^em1Kozi
• Name: macrophage expressed gene 1; endonuclease-mediated mutation 1, Patrycja Kozik
• MGI ID: MGI:7507078
• Gene: Mpeg1 Location: Chr19:12438143-12442649 bp, + strand Genetic Position: Chr19, 8.72 cM
• Alliance: Mpeg1^em1Kozi page

Mutation origin

• Strain of Origin: Not Specified

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: CRISPR-cas9 mediated recombination using guide RNAs created a 17 bp deletion in exon 2 spanning from bases 525 to 541. (J:337206)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mpeg1 Mutation: 54 strains or lines available

References

• Original: J:337206 Rodriguez-Silvestre P, et al., Perforin-2 is a pore-forming effector of endocytic escape in cross-presenting dendritic cells. Science. 2023 Jun 23;380(6651):1258-1265
• All: 1 reference(s)