Ch25h^em1Rebo
Endonuclease-mediated Allele Detail

Summary

• Symbol: Ch25h^em1Rebo
• Name: cholesterol 25-hydroxylase; endonuclease-mediated mutation 1, Andrea Reboldi
• MGI ID: MGI:7507023
• Synonyms: Ch25h^flox
• Gene: Ch25h Location: Chr19:34451183-34452548 bp, - strand Genetic Position: Chr19, 29.69 cM
• Alliance: Ch25h^em1Rebo page

Mutation origin

• Strain of Origin: Not Specified

Mutation description

• Allele Type: Endonuclease-mediated (Conditional ready)
• Mutation: Insertion
• Mutation details: CRISPR-cas9 mediated recombination inserted loxP sites 690 bp 5' and 20 bp 3' to the single coding exon. (J:337671)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ch25h Mutation: 23 strains or lines available

References

• Original: J:337671 Ceglia S, et al., An epithelial cell-derived metabolite tunes immunoglobulin A secretion by gut-resident plasma cells. Nat Immunol. 2023 Mar;24(3):531-544
• All: 3 reference(s)