Ppy^{em1(rtTA)Herr}
Endonuclease-mediated Allele Detail

Summary

• Symbol: Ppy^{em1(rtTA)Herr}
• Name: pancreatic polypeptide; endonuclease-mediated mutation 1, Pedro L Herrera
• MGI ID: MGI:7506998
• Synonyms: Ppy-rtTA
• Gene: Ppy Location: Chr11:101990757-101992145 bp, - strand Genetic Position: Chr11, 65.48 cM
• Alliance: Ppy^{em1(rtTA)Herr} page

Mutation origin

• Strain of Origin: Not Specified

Mutation description

• Allele Type: Endonuclease-mediated (Transactivator)
• Mutations: Insertion, Intragenic deletion
• Mutation details: CRISPR-cas9 mediated recombination replaced a genomic region spanning exons 2 and 3 with a doxycycline-dependent reverse transactivator coding region. (J:337676)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ppy Mutation: 11 strains or lines available

References

• Original: J:337676 Perez-Frances M, et al., Pancreatic Ppy-expressing gamma-cells display mixed phenotypic traits and the adaptive plasticity to engage insulin production. Nat Commun. 2021 Jul 22;12(1):4458
• All: 2 reference(s)