Ace2^em1Nma
Endonuclease-mediated Allele Detail

Summary

• Symbol: Ace2^em1Nma
• Name: angiotensin converting enzyme 2; endonuclease-mediated mutation 1, Nixon M Abraham
• MGI ID: MGI:7506623
• Gene: Ace2 Location: ChrX:162922338-162971414 bp, + strand Genetic Position: ChrX, 76.12 cM, cytoband F5
• Alliance: Ace2^em1Nma page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: CRISPR/Cas9 technology targeting the translation start site in exon 2 generated a 246 bp deletion. Western blot analysis confirmed absence of protein in the brain of homozygotes. (J:337720)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ace2 Mutation: 73 strains or lines available

References

• Original: J:337720 Mahajan S, et al., Knockout of angiotensin converting enzyme-2 receptor leads to morphological aberrations in rodent olfactory centers and dysfunctions associated with sense of smell. Front Neurosci. 2023;17:1180868
• All: 1 reference(s)