Pten^tm3.1Mak
Targeted Allele Detail

Summary

• Symbol: Pten^tm3.1Mak
• Name: phosphatase and tensin homolog; targeted mutation 3.1, Tak Mak
• MGI ID: MGI:7506316
• Synonyms: Pten^398A
• Gene: Pten Location: Chr19:32734977-32803560 bp, + strand Genetic Position: Chr19, 28.14 cM
• Alliance: Pten^tm3.1Mak page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:314706
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Not Specified)
• Mutation: Single point mutation
• Mutation details: Serine codon 398 (TCA) in exon 9 was changed to alanine (GCA) (p.S398A). The loxP and FRT site flanked neomycin resistance gene cassette that was inserted was removed through subsequent Flp-mediated recombination. The mutation prevents phosphorylation of the residue in the encoded peptide. (J:314706)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pten Mutation: 86 strains or lines available

References

• Original: J:314706 Bassi C, et al., The PTEN and ATM axis controls the G1/S cell cycle checkpoint and tumorigenesis in HER2-positive breast cancer. Cell Death Differ. 2021 Nov;28(11):3036-3051
• All: 1 reference(s)