Tg(Cyp1a1-ALPP)1Mktm
Transgene Detail

Summary

• Symbol: Tg(Cyp1a1-ALPP)1Mktm
• Name: transgene insertion 1, Masanori Kitamura
• MGI ID: MGI:7506292
• Synonyms: Tg(DRE-SEAP)
• Transgene: Tg(Cyp1a1-ALPP)1Mktm Location: unknown
• Alliance: Tg(Cyp1a1-ALPP)1Mktm page

Transgene origin

• Strain of Origin: Not Applicable

Transgene description

• Transgene Type: Transgenic (Inducible, Inserted expressed sequence)
• Mutation: Insertion
• Tg(Cyp1a1-ALPP)1Mktm expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  ALPP (250)

  Akp3	(MGI:87984)
  Alpi	(MGI:1924018)
  Alppl2	(MGI:108009)

• Tg(Cyp1a1-ALPP)1Mktm expression driven by 1 gene
  Transgene expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Cyp1a1 (MGI:88588)

• Mutation details: MMTV-DRE promoter [1.8 kb regulatory fragment consists of the following two parts: (1)a 484-bp fragment from the upstream region of the mouse Cyp1A1 gene that contains 4 dioxin responsive elements (DRE), and (2) a 1330-bp fragment from a part of the mouse mammary tumor virus (MMTV) promoter lacking in glucocorticoid responsive enhancers] driving inducible expression of human secreted alkaline phoaphatase cDNA with an SV40 Late mRNA poly A. (J:337738)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:337738 Hiramatsu N, et al., Real-time detection and continuous monitoring of ER stress in vitro and in vivo by ES-TRAP: evidence for systemic, transient ER stress during endotoxemia. Nucleic Acids Res. 2006;34(13):e93
• All: 1 reference(s)