Rorb^hstp-5J
Spontaneous Allele Detail

Summary

• Symbol: Rorb^hstp-5J
• Name: RAR-related orphan receptor beta; high stepper 5 Jackson
• MGI ID: MGI:7505585
• Synonyms: h5
• Gene: Rorb Location: Chr19:18907969-19088560 bp, - strand Genetic Position: Chr19, 13.28 cM
• Alliance: Rorb^hstp-5J page

Mutation origin

• Strain of Origin: Not Applicable

Mutation description

• Allele Type: Spontaneous (Modified isoform(s))
• Mutation: Single point mutation
• Mutation details: This spontaneous thymine to cytosine point substitution in the ATG start codon of exon 1a has exon 3 as the next in-frame start codon so is predicted to cause a start-loss variant disrupting the first zinc finger domain. Expression of the Rorb1 transcript in brain and retina is significantly increased and the Rorb2 transcript significantly decreased in retina. (J:337403)
• Inheritance: Recessive

Expression

In Mice Carrying this Mutation:

1 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rorb Mutation: 39 strains or lines available

References

• Original: J:337403 Murray GC, et al., An allelic series of spontaneous Rorb mutant mice exhibit a gait phenotype, changes in retina morphology and behavior, and gene expression signatures associated with the unfolded protein response. G3 (Bethesda). 2023 Jun 10
• All: 1 reference(s)