Sphk2^em1Mzha
Endonuclease-mediated Allele Detail

Summary

• Symbol: Sphk2^em1Mzha
• Name: sphingosine kinase 2; endonuclease-mediated mutation 1, Meijia Zhang
• MGI ID: MGI:7505576
• Synonyms: Sphk2^fl
• Gene: Sphk2 Location: Chr7:45358891-45367426 bp, - strand Genetic Position: Chr7, 29.45 cM
• Alliance: Sphk2^em1Mzha page

Mutation origin

• Strain of Origin: Not Specified

Mutation description

• Allele Type: Endonuclease-mediated (Conditional ready)
• Mutation: Insertion
• Exons 4 to 6 were flanked by loxP sites via CRISPR/Cas9 technology. (J:337626)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Sphk2 Mutation: 38 strains or lines available

References

• Original: J:337626 Yuan F, et al., SphK-produced S1P in somatic cells is indispensable for LH-EGFR signaling-induced mouse oocyte maturation. Cell Death Dis. 2022 Nov 17;13(11):963
• All: 1 reference(s)