Del(7Saa1-Saa2)1Itl
Targeted Allele Detail

Summary

• Symbol: Del(7Saa1-Saa2)1Itl
• Name: deletion, Chr 7, inGenious Targeting Laboratory
• MGI ID: MGI:7496047
• Synonyms: SAA1.1/SAA2.1^-, Saa1/Saa2^tm1Itl
• Gene: Del(7Saa1-Saa2)1Itl Location: unknown Genetic Position: Chr7, Syntenic

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:165605
• Parent Cell Line: iTL BA1 (ES Cell)
• Strain of Origin: (C57BL/6NTac x 129S6/SvEvTac)F1

Mutation description

Allele Type: Targeted (Null/knockout) Mutations: Insertion, Intergenic deletion Del(7Saa1-Saa2)1Itl involves 2 genes/genome features (Saa1, Saa2) View all Mutation details: 10.1 kb of genomic sequence, including exons 1 and 2 of Saa1 and Saa2 and the intervening sequence, was replaced with a loxP/FRT-flanked neomycin selection cassette. The absence of protein expression of both genes was confirmed by western blot analysis. (J:165605)

Generation of the MGI:4838092 allele

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Del(7Saa1-Saa2)1Itl Mutation: 2 strains or lines available

References

• Original: J:165605 de Beer MC, et al., Impact of serum amyloid A on High Density Lipoprotein composition and levels. J Lipid Res. 2010 Nov;51(11):3117-25
• All: 25 reference(s)