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Dis3em2Dean
Endonuclease-mediated Allele Detail
Summary
Symbol: Dis3em2Dean
Name: DIS3 homolog, exosome endoribonuclease and 3'-5' exoribonuclease; endonuclease-mediated mutation 2, Jurien Dean
MGI ID: MGI:7495790
Synonyms: Dis3-null
Gene: Dis3  Location: Chr14:99314070-99337217 bp, - strand  Genetic Position: Chr14, 49.25 cM, cytoband E2.1
Alliance: Dis3em2Dean page
Mutation
origin
Strain of Origin:  (C57BL/6 x DBA/2)F1
Mutation
description
Allele Type:    Endonuclease-mediated (Null/knockout)
Mutation:    Intragenic deletion
    CRISPR/Cas9 genome editing tecnology was used to generate a deletion encompassing exons 3-5. (J:333394)
Expression
In Mice Carrying this Mutation: 5 RNA-Seq or microarray experiment(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Dis3 Mutation:  41 strains or lines available
References
Original:  J:333394 Wu D, et al., RNA exosome ribonuclease DIS3 degrades Pou6f1 to promote mouse pre-implantation cell differentiation. Cell Rep. 2023 Jan 30;42(2):112047
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/18/2025
MGI 6.24
The Jackson Laboratory