Myh10^m1Dyrs
Chemically induced Allele Detail

Summary

• Symbol: Myh10^m1Dyrs
• Name: myosin, heavy polypeptide 10, non-muscle; mutation 1, Didier YR Stainier
• MGI ID: MGI:7494203
• Synonyms: MYH10^L458R
• Gene: Myh10 Location: Chr11:68582385-68707458 bp, + strand Genetic Position: Chr11, 41.95 cM, cytoband B3
• Alliance: Myh10^m1Dyrs page

Mutation origin

• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Chemically induced (ENU) (Hypomorph)
• Mutation: Single point mutation
• Mutation details: ENU mutagenesis induced a T to G point mutation responsible for the amino acid substitution of leucine with arginine at position 458 (L458R). (J:268349)
• Inheritance: Recessive

Expression

In Mice Carrying this Mutation:

1 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Myh10 Mutation: 95 strains or lines available

References

• Original: J:268349 Kim HT, et al., Myh10 deficiency leads to defective extracellular matrix remodeling and pulmonary disease. Nat Commun. 2018 Nov 2;9(1):4600
• All: 1 reference(s)