Tg(GPX4)6Vrmn
Transgene Detail

Summary

• Symbol: Tg(GPX4)6Vrmn
• Name: transgene insertion 6, Holly Van Remmen
• MGI ID: MGI:7494189
• Synonyms: Tg(GPX4)
• Transgene: Tg(GPX4)6Vrmn Location: unknown
• Alliance: Tg(GPX4)6Vrmn page

Transgene origin

• Strain of Origin: B6D2F1

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(GPX4)6Vrmn expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  GPX4 (2879)

  Gpx4	(MGI:104767)

• Tg(GPX4)6Vrmn expression driven by 1 gene
  Transgene expression driven by:
  

  Organism

  Driver Gene

  Homolog in Mouse

  Note

  human

  GPX4 (2879)

  Gpx4	(MGI:104767)

• Mutation details: A human P1 clone, containing the intact human GPX4 gene (about 3 kb) plus about 30 and 20 kb of 5'- and 3'-flanking sequence, respectively, was used to generate transgenic mice. (J:94555)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:94555 Ran Q, et al., Transgenic mice overexpressing glutathione peroxidase 4 are protected against oxidative stress-induced apoptosis. J Biol Chem. 2004 Dec 31;279(53):55137-46
• All: 11 reference(s)