Kmt2e^em1Zhay
Endonuclease-mediated Allele Detail

Summary

• Symbol: Kmt2e^em1Zhay
• Name: lysine (K)-specific methyltransferase 2E; endonuclease-mediated mutation 1, Yan Zhang
• MGI ID: MGI:7494175
• Gene: Kmt2e Location: Chr5:23639439-23709233 bp, + strand Genetic Position: Chr5, 10.33 cM, cytoband A3
• Alliance: Kmt2e^em1Zhay page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• CRISPR-cas9 mediated recombination created an 8 bp deletion (TGCATATG) in exon 3. (J:260756)

Expression

In Mice Carrying this Mutation:

1 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Kmt2e Mutation: 104 strains or lines available

References

• Original: J:260756 Zhou P, et al., MLL5 suppresses antiviral innate immune response by facilitating STUB1-mediated RIG-I degradation. Nat Commun. 2018 Mar 28;9(1):1243
• All: 2 reference(s)