Ube3a^{em1(IMPC)Ccpcz}
Endonuclease-mediated Allele Detail

Summary

• Symbol: Ube3a^{em1(IMPC)Ccpcz}
• Name: ubiquitin protein ligase E3A; endonuclease-mediated mutation 1, Institute of Molecular Genetics
• MGI ID: MGI:7494064
• Synonyms: Ube3a^Genedel
• Gene: Ube3a Location: Chr7:58878498-58961284 bp, + strand Genetic Position: Chr7, 33.95 cM
• Alliance: Ube3a^{em1(IMPC)Ccpcz} page
• IMPC: Ube3a gene page

Mutation origin

• Strain of Origin: C57BL/6NCrl
• Project Collection: IMPC

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: CRISPR/Cas9 genome editing technology was used to generate a 76,225 bp deletion spanning the entire gene. (J:337153)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ube3a Mutation: 73 strains or lines available

References

• Original: J:337153 Syding LA, et al., Generation and Characterization of a Novel Angelman Syndrome Mouse Model with a Full Deletion of the Ube3a Gene. Cells. 2022 Sep 9;11(18)
• All: 1 reference(s)