Ubqln1^em1Hlp
Endonuclease-mediated Allele Detail

Summary

• Symbol: Ubqln1^em1Hlp
• Name: ubiquilin 1; endonuclease-mediated mutation 1, Henry L Paulson
• MGI ID: MGI:7493913
• Gene: Ubqln1 Location: Chr13:58323970-58363467 bp, - strand Genetic Position: Chr13, 30.95 cM
• Alliance: Ubqln1^em1Hlp page

Mutation origin

• Strain of Origin: Not Applicable

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: CRISPR/Cas9 technology deleted exons 2 and 3 which introduced a premature stop codon after splicing from exon 1 to 4. (J:336757)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ubqln1 Mutation: 22 strains or lines available

References

• Original: J:336757 Mohan HM, et al., RTL8 promotes nuclear localization of UBQLN2 to subnuclear compartments associated with protein quality control. Cell Mol Life Sci. 2022 Mar 5;79(3):176
• All: 1 reference(s)