Iars1^em1Nsas
Endonuclease-mediated Allele Detail

Summary

• Symbol: Iars1^em1Nsas
• Name: isoleucyl-tRNA synthetase 1; endonuclease-mediated mutation 1, Nobuya Sasaki
• MGI ID: MGI:7493275
• Synonyms: Iars^em1Nsas
• Gene: Iars1 Location: Chr13:49835606-49887743 bp, + strand Genetic Position: Chr13, 25.38 cM
• Alliance: Iars1^em1Nsas page

Mutation origin

• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: A knockout allele was generated by introducing a 2-bp deletion in exon 3 using CRISPR/Cas9-mediated genome editing. The deletion (AG) occurs within exon 3 at codon 74 and leads to a frameshift mutation of the coding region. (J:380164)
• Inheritance: Not Specified

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Iars1 Mutation: 84 strains or lines available

References

• Original: J:380164 Watanabe Y, et al., Isoleucyl-tRNA synthetase 1 is essential for embryogenesis in mice. J Vet Med Sci. 2026 Jan 16;88(1):126-130
• All: 1 reference(s)