Gt(ROSA)26Sor^{tm3(Pik3ca*E545K)Egan}
Targeted Allele Detail

Summary

• Symbol: Gt(ROSA)26Sor^{tm3(Pik3ca*E545K)Egan}
• Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 3, Sean E Egan
• MGI ID: MGI:7493251
• Gene: Gt(ROSA)26Sor Location: Chr6:113044389-113054205 bp, - strand Genetic Position: Chr6, 52.73 cM
• Alliance: Gt(ROSA)26Sor^{tm3(Pik3ca*E545K)Egan} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:270695
• Parent Cell Line: W4 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Conditional ready, Inserted expressed sequence)
• Mutation: Insertion
• Gt(ROSA)26Sor^{tm3(Pik3ca*E545K)Egan} expresses 1 gene
  Knock-in expresses:
  

  Organism	Expressed Gene	Note
  mouse	Pik3ca (MGI:1206581)

• Mutation details: The following sequences were inserted into intron 1: splice acceptor site, a STOP cassette (loxP site flanked neomycin resistance gene cassette), Pik3ca cDNA sequence where glutamic acid codon 545 (GAA) was changed to lysine (p.E545K), and bovine GH poly(A) signal sequences. (J:270695)
• Inheritance: Not Specified

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gt(ROSA)26Sor Mutation: 944 strains or lines available

References

• Original: J:270695 An Y, et al., Cdh1 and Pik3ca Mutations Cooperate to Induce Immune-Related Invasive Lobular Carcinoma of the Breast. Cell Rep. 2018 Oct 16;25(3):702-714.e6
• All: 2 reference(s)