Pgm1^em3Laik
Endonuclease-mediated Allele Detail

Summary

• Symbol: Pgm1^em3Laik
• Name: phosphoglucomutase 1; endonuclease-mediated mutation 3, Kent Lai
• MGI ID: MGI:7492199
• Synonyms: Pgm2^fl
• Gene: Pgm1 Location: Chr4:99786648-99844491 bp, + strand Genetic Position: Chr4, 45.71 cM
• Alliance: Pgm1^em3Laik page

Mutation origin

• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Endonuclease-mediated (Conditional ready)
• Mutation: Insertion
• LoxP sites were inserted into introns 1 and 2 using an ssODN template with CRISPR/Cas9 technology. (J:337793)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pgm1 Mutation: 37 strains or lines available

References

• Original: J:337793 Balakrishnan B, et al., AAV-based gene therapy prevents and halts the progression of dilated cardiomyopathy in a mouse model of phosphoglucomutase 1 deficiency (PGM1-CDG). Transl Res. 2023 Jul;257:1-14
• All: 1 reference(s)