Cux1^em1Kzy
Endonuclease-mediated Allele Detail

Summary

• Symbol: Cux1^em1Kzy
• Name: cut-like homeobox 1; endonuclease-mediated mutation 1, Kazuhiro Yamakawa
• MGI ID: MGI:7490364
• Synonyms: Casp^-
• Gene: Cux1 Location: Chr5:136276989-136596344 bp, - strand Genetic Position: Chr5, 75.96 cM
• Alliance: Cux1^em1Kzy page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Modified isoform(s))
• Mutation: Insertion
• Mutation details: CRISPR/Cas9 technology targeting exon 17 at the unique C-terminus inserted 2-bp (TT) between c.1514 and c.1515, resulting in a frameshift (p.S506fs). (J:325310)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cux1 Mutation: 116 strains or lines available

References

• Original: J:325310 Suzuki T, et al., CUX2 deficiency causes facilitation of excitatory synaptic transmission onto hippocampus and increased seizure susceptibility to kainate. Sci Rep. 2022 May 17;12(1):6505
• All: 1 reference(s)