Gt(ROSA)26Sor^{tm1(CAG-Wnt5a)Tpy}
Targeted Allele Detail

Summary

• Symbol: Gt(ROSA)26Sor^{tm1(CAG-Wnt5a)Tpy}
• Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 1, Terry Yamaguchi
• MGI ID: MGI:7490307
• Synonyms: Rosa26^Wnt5a
• Gene: Gt(ROSA)26Sor Location: Chr6:113044389-113054205 bp, - strand Genetic Position: Chr6, 52.73 cM
• Alliance: Gt(ROSA)26Sor^{tm1(CAG-Wnt5a)Tpy} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:236315
• Parent Cell Line: Bruce 4 (ES Cell)
• Strain of Origin: B6.Cg-Thy1^a

Mutation description

• Allele Type: Targeted (Inserted expressed sequence)
• Mutation: Insertion
• Gt(ROSA)26Sor^{tm1(CAG-Wnt5a)Tpy} expresses 1 gene
  Knock-in expresses:
  

  Organism	Expressed Gene	Note
  mouse	Wnt5a (MGI:98958)

• Gt(ROSA)26Sor^{tm1(CAG-Wnt5a)Tpy} expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  chicken	CAG

• Mutation details: A floxed-STOP-Wnt3a-IRES-AcGFP-Nuc cassette, driven by a CAG promoter, was inserted between exons 1 and 2 of the Rosa26 gene. (J:236315)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gt(ROSA)26Sor Mutation: 1089 strains or lines available

References

• Original: J:236315 Chalamalasetty RB, et al., A new gain-of-function mouse line to study the role of Wnt3a in development and disease. Genesis. 2016 Sep;54(9):497-502
• All: 2 reference(s)