Parp3^em1Wsk
Endonuclease-mediated Allele Detail

Summary

• Symbol: Parp3^em1Wsk
• Name: poly (ADP-ribose) polymerase family, member 3; endonuclease-mediated mutation 1, David Weinstock
• MGI ID: MGI:7490242
• Gene: Parp3 Location: Chr9:106347521-106354148 bp, - strand Genetic Position: Chr9, 57.58 cM
• Alliance: Parp3^em1Wsk page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:336603
• Parent Cell Line: TC1/TC-1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• CRISPR-targeting deleted a 492-bp region containing two of the three catalytic residues. (J:336603)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Parp3 Mutation: 34 strains or lines available

References

• Original: J:336603 Layer JV, et al., Parp3 promotes long-range end joining in murine cells. Proc Natl Acad Sci U S A. 2018 Oct 2;115(40):10076-10081
• All: 1 reference(s)