Trem2^em1(cre)Jddl
Endonuclease-mediated Allele Detail

Summary

• Symbol: Trem2^em1(cre)Jddl
• Name: triggering receptor expressed on myeloid cells 2; endonuclease-mediated mutation 1, Jiandie D Lin
• MGI ID: MGI:7490214
• Synonyms: Trem2-Cre
• Gene: Trem2 Location: Chr17:48653429-48659304 bp, + strand Genetic Position: Chr17, 23.99 cM, cytoband C
• Alliance: Trem2^em1(cre)Jddl page

Mutation origin

• Strain of Origin: Not Specified

Mutation description

• Allele Type: Endonuclease-mediated (Recombinase)
• Mutation: Insertion
• Trem2^em1(cre)Jddl expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Trem2 (MGI:1913150)

• Mutation details: Using the CRISPR knockin strategy the Cre recombinase was insetted to endogenous Trem2 via the self-cleavage P2A peptide. (J:329206)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Trem2 (mouse) Summary of all recombinase alleles driven by Trem2. Comparative matrix view of recombinase activities Alliance mouse Trem2 gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Trem2 Mutation: 65 strains or lines available

Notes

The mouse line was terminated due to low recombinase activity detected.

References

• Original: J:329206 Zhang P, et al., Neuregulin 4 suppresses NASH-HCC development by restraining tumor-prone liver microenvironment. Cell Metab. 2022 Sep 6;34(9):1359-1376.e7
• All: 1 reference(s)