Serf2tm1b(KOMP)Wtsi
Targeted Allele Detail
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Symbol: |
Serf2tm1b(KOMP)Wtsi |
Name: |
small EDRK-rich factor 2; targeted mutation 1b, Wellcome Trust Sanger Institute |
MGI ID: |
MGI:7490114 |
Gene: |
Serf2 Location: Chr2:121279679-121283901 bp, + strand Genetic Position: Chr2, 60.39 cM
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Alliance: |
Serf2tm1b(KOMP)Wtsi page
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IMPC: |
Serf2 gene page |
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Germline Transmission: |
Earliest citation of germline transmission:
J:335458
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Parent Cell Line: |
JM8.N4 (ES Cell)
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Strain of Origin: |
C57BL/6N
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Project Collection: |
KOMP-CSD
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Allele Type: |
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Targeted (Null/knockout, Reporter) |
Mutations: |
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Insertion, Intragenic deletion
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Mutation details: The L1L2_Bact_P cassette was inserted at position 121280074 of Chromosome 2 upstream of the critical exon(s) (Build GRCm39). The cassette is composed of an FRT site followed by lacZ sequence and a loxP site. This first loxP site is followed by a neomycin resistance gene under the control of the human beta-actin promoter, SV40 polyA, a second FRT site and a second loxP site. A third loxP site is inserted downstream of the targeted exon(s) at position 121280144. The critical exon(s) is/are thus flanked by loxP sites. Cre expression occurs without flp expression created a reporter knockout mouse. Further information on targeting strategies used for this and other IKMC alleles can be found at http://www.informatics.jax.org/mgihome/nomen/IKMC_schematics.shtml
(J:335458)
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Serf2 Mutation: |
14 strains or lines available
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Original: |
J:335458 Stroo E, et al., Deletion of SERF2 in mice delays embryonic development and alters amyloid deposit structure in the brain. Life Sci Alliance. 2023 Jul;6(7):e202201730 |
All: |
1 reference(s) |
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