Tmem168^em1Osb
Endonuclease-mediated Allele Detail

Summary

• Symbol: Tmem168^em1Osb
• Name: transmembrane protein 168; endonuclease-mediated mutation 1, Research Institute for Microbial Diseases, Osaka University
• MGI ID: MGI:7489974
• Synonyms: Tmem168^{em1(R539Q)Osb}
• Gene: Tmem168 Location: Chr6:13580688-13608097 bp, - strand Genetic Position: Chr6, 5.68 cM, cytoband A2
• Alliance: Tmem168^em1Osb page

Mutation origin

• Strain of Origin: (C57BL/6 x DBA)F2

Mutation description

• Allele Type: Endonuclease-mediated (Not Specified)
• Mutation: Single point mutation
• Mutation details: CRISPR-targeting introduced the amino acid substitution arginine with glutamine at position 539 (R539Q). (J:303083)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tmem168 Mutation: 34 strains or lines available

References

• Original: J:303083 Shimizu A, et al., Identification of transmembrane protein 168 mutation in familial Brugada syndrome. FASEB J. 2020 May;34(5):6399-6417
• All: 1 reference(s)