Ybx3^tm1Reb
Targeted Allele Detail

Summary

• Symbol: Ybx3^tm1Reb
• Name: Y box protein 3; targeted mutation 1, Robert E Braun
• MGI ID: MGI:7489664
• Synonyms: Ybx3 KO
• Gene: Ybx3 Location: Chr6:131341821-131365413 bp, - strand Genetic Position: Chr6, 63.44 cM
• Alliance: Ybx3^tm1Reb page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:269044
• Parent Cell Line: A3-1 (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: An attempt to insert a 5 loxP site between exons 1 and 2 and a 3 loxP site between exons 3 and 4 of the gene was made but an unexpected recombination event resulted in insertion of a single loxP site and the neomycin selection cassette upstream of exon 4, leading to disruption of the endogenous Ybx3 locus. (J:269044)

Expression

In Mice Carrying this Mutation:

1 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ybx3 Mutation: 29 strains or lines available

References

• Original: J:269044 Snyder E, et al., Compound Heterozygosity for Y Box Proteins Causes Sterility Due to Loss of Translational Repression. PLoS Genet. 2015 Dec;11(12):e1005690
• All: 1 reference(s)