Crybb1^em3Cln
Endonuclease-mediated Allele Detail

Summary

• Symbol: Crybb1^em3Cln
• Name: crystallin, beta B1; endonuclease-mediated mutation 3, Marco Colonna
• MGI ID: MGI:7488432
• Synonyms: Crybb1^-, Crybb1 knock-out
• Gene: Crybb1 Location: Chr5:112403686-112417451 bp, + strand Genetic Position: Chr5, 54.63 cM
• Alliance: Crybb1^em3Cln page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: Using CRISPR/Cas9 endonuclease-mediated genome editing, an out-of-frame deletion of 177bp in exon 3 of the crystallin, beta B1 (Crybb1) gene on chromosome 5 was generated. (J:334326)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Crybb1 Mutation: 10 strains or lines available

References

• Original: J:334326 Brioschi S, et al., A Cre-deleter specific for embryo-derived brain macrophages reveals distinct features of microglia and border macrophages. Immunity. 2023 Feb 8
• All: 1 reference(s)