Tg(ACTA1-rtTA)6Mcrth
Transgene Detail

Summary

• Symbol: Tg(ACTA1-rtTA)6Mcrth
• Name: transgene insertion 6, John McCarthy
• MGI ID: MGI:7488164
• Synonyms: HSA-rtTA
• Transgene: Tg(ACTA1-rtTA)6Mcrth Location: unknown Genetic Position: ChrUN, Syntenic
• Alliance: Tg(ACTA1-rtTA)6Mcrth page

Transgene origin

• Strain of Origin: C57BL/6 x SJL

Transgene description

• Transgene Type: Transgenic (Transactivator)
• Mutation: Insertion
• Mutation details: The transgenic construct contains a human skeletal muscle alpha actin promoter and first exon (- 2,000 to + 239 relative to the transcription start site) promoter, a beta-globin intron II and a poly(A) tail followed by a modified reverse tetracycline-regulated transactivator (rtTA) from Tet3G. Mice from founder line 6 were found to have robust H2B-GFP expression in both slow- and fast-twitch muscles of the lower hind limbs. (J:336174)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:336174 Iwata M, et al., A novel tetracycline-responsive transgenic mouse strain for skeletal muscle-specific gene expression. Skelet Muscle. 2018 Oct 27;8(1):33
• All: 4 reference(s)